New de novo assembler for next generation sequencing data in BioNumerics

Applied Maths NV today announces that it has released a new version of its flagship software suite BioNumerics that allows de novo assembly to be performed on next generation sequencing data. This new feature, available in version 6.6, consolidates the development of BioNumerics into a complete and fully integrated suite for preprocessing and analysis of NGS data.

The de novo assembly is available in BioNumerics’ new Power Assembler released in version 6.5 and is based on two open source third party tools: Velvet & Ray. Both applications are GPL-licensed, and have been revised to compile under Windows in 32 bit as well as 64 bit modes. Both assembly tools are complemented by an in-house developed greedy algorithm for final contig alignment. Additionally, several enhancements to the Power Assembler were included to relax the RAM requirements and to reduce calculation time of the assemblies. The assembler is designed to allow de novo assembly of full bacterial chromosomes on a regular desktop computer running a 64-bit Windows OS and having sufficient RAM.

To further increase the user-friendliness of the versatile pipeline design of the Power Assembler, project templates have been introduced. Predefined project templates are available for the most commonly used workflows, thus allowing beginning users to easily start the analysis of their data. All parameters of a template can easily be accessed and changed at any time later to guarantee the maximal flexibility and performance of the tool. Project templates can be saved and shared between co-workers.