Applied Maths joins international consortium for NGS based pathogen diagnostics and genotyping

Along with 6 leading research and knowledge centers across Europe, Applied Maths has entered into a consortium to develop a methodology for rapid and accurate diagnostics and genotyping of bacterial pathogens based upon Next Generation Sequencing. The consortium has successfully applied for a EU research project, Patho-NGen-Trace, which was launched on 1 January 2012. The project will run for 54 months and receive nearly 6 million Euros in funding from the European Union’s 7th Framework Programme. The international consortium consists of leading knowledge centers in the field of clinical microbiology, such as the Westfälische Wilhelms-University Muenster, the University of Oxford and the Research Center Borstel (scientific project coordinator), and expert enterprises in this area, including Applied Maths NV, Genoscreen SAS, Piext BV (representing OpGen, Inc. in Europe) and Ridom GmbH.

The project participants will develop Next Generation Sequencing methods combined with Whole Genome Mapping as groundbreaking DNA analysis tools into a highly efficient technology that can be used for the typing and diagnostics of pathogens. Three pathogens in particular will serve as models – the Mycobacterium tuberculosis complex, methicillin-resistant Staphylococcus aureus (MRSA), and Campylobacter species. All three pathogens are prevalent worldwide, posing a serious medical threat and an important challenge with respect to treatment and control. In the long run the consortium not only aims to control and predict, but also contain the spread of the three pathogens.

Stefan Niemann, Head of the Molecular Mycobacteriology Group at the Research Center Borstel and coordinator of the project, emphasizes the potential impact as follows: “Patho-NGen-Trace is developing the technology that will enable us to identify pathogens and their mutations much faster and with more precision. It will also help us detect drug-resistant strains even better.”

The consortium includes the following partners:

  • Research Center Borstel, Leibniz-Zentrum für Medizin und Biowissenschaften, Germany
  • Universitätsklinikum Westfälische Wilhelms-Universität Münster, Germany
  • University of Oxford, Department of Zoology, United Kingdom
  • Applied Maths NV, Belgium
  • Genoscreen SAS, France
  • Ridom GmbH, Germany
  • Piext BV, the Netherlands

More information can also be found at

About Applied Maths

Applied Maths, a bioinformatics company, was founded in 1992 and incorporated in 1994. Since then, it has gained global recognition with its software for the analysis of electrophoresis patterns. The company has acquired a unique market position with BioNumerics, a software suite for integrated databasing and analysis of all kinds of biological data. BioNumerics has developed into a multi-faceted platform combining databasing and analysis technologies, with numerous applications in research and diagnostics, including bacterial and viral epidemiology and profiling, plant improvement, human genetics and biotechnology.

Applied Maths combines extensive expertise in bioinformatics and unique mathematical know-how to develop the most powerful and fastest algorithms for pattern recognition and matching, data mining, screening and clustering. In so doing, the company fulfills a critical requirement in the bioinformatics industry for obtaining and analyzing greater and more complex data sets. The impact of Applied Maths' software is evidenced by referrals in thousands of scientific publications and an impressive portfolio of customers throughout the world. The BioNumerics software platform is used in many prestigious international projects and mission-critical networks.

Applied Maths has units in Sint-Martens-Latem (Belgium) (head office) and Austin (USA). For further information, please visit the company's website:

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