Development of a certified diagnostic test for monitoring disease activity in patients with inflammatory bowel disease

Coordinator: 
Prof. Paul Savelkoul (IS-Diagnostics Ltd.)
Project duration: 
01 Jun 2012 to 31 Oct 2014

Aim of the project: Development of a certified diagnostic test that monitors disease activity in patients with IBD using personal microbial profiling.

Main objectives:

  1. Next-generation sequencing of intestinal samples and IS-pro analysis of two cohorts of 150 anonymized patients with Crohn’s disease and ulcerative colitis respectively.
  2. Construction of next-generation sequencing assembly pipeline and analysis of resulting sequence data.
  3. Design of clinical diagnostic test parameters and initiation of CE/IVD registration.
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