PathoGenetix and Applied Maths to integrate rapid strain typing and bioinformatics tools

WOBURN, MA (USA) and SINT-MARTENS-LATEM (BELGIUM) - PathoGenetix, Inc., developer of an automated system for rapid bacterial identification, and Applied Maths, NV, a leader in bioinformatics and analytical solutions for public health and research laboratories, have signed a collaborative agreement to integrate the RESOLUTION™ Microbial Genotyping System with the BioNumerics™ software suite. The end-to-end automated solution will integrate rapid pathogen strain typing with advanced data management and networking tools, and enable sharing and comparison of outbreak strain data among public health or food safety testing labs. The collaboration also will enable serotype and strain type information generated by the RESOLUTION System to be compared to data sets generated by other identification methods such as pulsed field gel electrophoresis (PFGE) or whole genome sequencing (WGS).

Pathogenetix' RESOLUTION systemPathoGenetix’s RESOLUTION System is based on Genome Sequence Scanning™ (GSS™) technology initially developed to detect bio-threat pathogens in environmental samples. This breakthrough genotyping technology isolates and analyzes microbial DNA directly from complex mixtures, without the need for a pure culture. Rapid throughput scanning and proprietary software generate genomic barcodes based on the underlying sequence, and compare them to an onboard database to provide molecular serotype and strain type information for all target bacteria present in the sample at detectable levels.

The typing resolution is comparable to PFGE, the current standard for pathogen identification in foodborne illness outbreak investigations. The RESOLUTION System’s ability to work from a mixed sample could enable it to provide critical strain information in a culture independent diagnostics environment.

“The RESOLUTION System with BioNumerics software will offer public health and food testing labs the ability to seamlessly integrate, curate and compare new outbreak strain information with their existing PFGE and whole genome sequence data sets,” said PathoGenetix president Ann Merrifield. “With time-to-results reduced to just five hours, and a seamless connection to existing strain databases and laboratory tools, we can shorten outbreak investigation and response, and improve public health,” Merrifield said.

Applied Maths’ BioNumerics is a turnkey software suite for integrative biological data management and comparative analysis that includes data mining, clustering, identification and statistical applications. BioNumerics software is currently in use in thousands of public and private research sites and laboratories worldwide, and is the cornerstone for numerous national and international research projects and epidemiological surveillance networks.

“We’re excited to work with PathoGenetix to link its breakthrough microbial identification technology with the BioNumerics software suite,” said Koen Janssens, chief executive officer of Applied Maths. “By working directly from a complex sample rather than a cultured isolate, and by automating pathogen identification from sample preparation to data analysis, our integrated solution will simplify laboratory workflows and dramatically reduce the time required to identify pathogenic organisms in epidemiological investigations.”

About PathoGenetix, Inc.

PathoGenetix, Inc. is a commercial-stage developer of an automated system for rapid bacterial identification from complex samples. PathoGenetix is a venture-backed company that has received more than $50 million in technology development funding from the Department of Homeland Security. The company’s core Genome Sequence Scanning™ (GSS™) technology isolates and analyzes DNA directly from an enriched biological sample—without the need for a cultured isolate—and provides results in just five hours, days faster than current methods. GSS has broad applicability in food safety, industrial microbiology, and clinical diagnostics and research. The first commercial GSS system will be available in 2014 for use in food safety testing and foodborne illness outbreak investigations. Learn more at www.pathogenetix.com.

About Applied Maths

Applied Maths, a bioinformatics company, was founded in 1992 and incorporated in 1994. Since then, it has gained global recognition with its software for the analysis of electrophoresis patterns. The company has acquired a unique market position with BioNumerics™, a software suite for integrated databasing and analysis of all kinds of biological data. BioNumerics has developed into a multi-faceted platform combining databasing and analysis technologies, with numerous applications in research and surveillance, including bacterial and viral epidemiology and profiling, crop improvement, human genetics and biotechnology.

Applied Maths combines extensive expertise in bioinformatics and unique mathematical know-how to develop the most powerful and fastest algorithms for pattern recognition and matching, data mining, screening and clustering. In so doing, the company fulfills a critical requirement in the bioinformatics industry for obtaining and analyzing greater and more complex data sets. The impact of Applied Maths’ software is evidenced by referrals in thousands of scientific publications and an impressive portfolio of customers in over 100 countries. The BioNumerics software platform is used in many prestigious international projects and mission-critical networks. Applied Maths has its headquarters in Sint-Martens-Latem (Belgium) and a sales office in Austin, TX (USA). For further information, please visit the company’s website: www.applied-maths.com

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