BioNumerics version 5.1 – A new dimension in sequence analysis
Sint-Martens-Latem, Belgium, January 9, 2008 – Applied Maths NV today announces the release of version 5.1 of its flagship software suite BioNumerics. The BioNumerics software provides a universal platform for databasing and analysis of 1D patterns, 2D gels, phenotype arrays, and DNA/protein sequences. The software provides powerful databasing, integrated networking and a wide range of data mining, clustering, identification, and statistical applications. BioNumerics is designed for lab-wide databasing and analysis of biodata in laboratories of any size and is in use in thousands of public and private research sites worldwide. The software is referenced in more than 1,300 peer-reviewed scientific papers. In addition, BioNumerics and its server application 'BioNumerics Server' are the cornerstones for numerous national and international research projects and epidemiological surveillance networks. PulseNet (www.cdc.gov/pulsenet), a worldwide surveillance network for foodborne bacterial pathogens is the foremost achievement with BioNumerics, connecting many hundreds of public health labs in the United States, Canada, Europe, Latin America, the Far East, Australia and New Zealand.
The highlight of BioNumerics version 5.1 is its new and innovative sequence alignment editor. Through an ingenious design, the alignment window combines the possibilities of a contig assembler, an advanced multiple alignment editor, a phylogenetic clustering program and a SNP/mutation discovery and analysis application. Original sequence trace chromatograms remain always visible in any step of the analysis, regardless of its complexity. Sequences or doubtful positions can thus easily be inspected for correctness. The program calculates confidence values for the sequence positions based on PHRED curve quality parameters, which in turn can be applied statistically for assigning reliability scores to potential SNP positions or mutations. BioNumerics’ holistic approach for sequence analysis offers great potential for critical applications that often rely on single base substitutions such as SNP discovery and derived diagnostic applications, HIV drug resistance analysis, multilocus sequence typing, etc. Sequences as long as full chromosomes can be analyzed, making the tool suitable for large-scale projects such as SNP analysis on fully sequenced or draft-sequenced chromosomes. A full list of new features in BioNumerics version 5.1 can be viewed on the website of Applied Maths.
Besides these general innovations, BioNumerics version 5.1 offers not less than 15 well-documented plugins, designed for highly specialized applications such as geographical mapping, MLST-typing, VNTR/MLVA-typing, MRSA-spa typing, HIV drug resistance prediction, HDA/CSCE mutation analysis, antibiotics susceptibility analysis, etc.
About Applied Maths
Applied Maths, a bioinformatics company, was set up in 1992 and incorporated in 1994. Since then, it has gained global recognition with its software for the analysis of electrophoresis patterns. The company has acquired a unique market position with BioNumerics, a software suite for integrated databasing and the analysis of all kinds of biodata. BioNumerics has developed into a multi-faceted platform combining databasing and analysis technologies, with numerous applications in research and diagnostics, including in bacterial and viral epidemiology and profiling, plant improvement, human genetics and biotechnology.
Applied Maths combines extensive expertise in bioinformatics and unique mathematical know-how to develop the most powerful and fastest algorithms for pattern recognition and matching, data mining, screening and clustering. In so doing, the company fulfills a critical requirement in the bioinformatics industry for obtaining and analysing greater and more complex data sets. The impact of Applied Maths' software is evidenced by referrals in more than 1300 scientific publications and an impressive portfolio of customers in the academic, industrial, clinical and public sectors in more that eighty countries throughout the world. The BioNumerics software platform is used in many prestigious international projects and networks.
In 2006 Applied Maths has entered into a financial partnership with KBC Private Equity and KBC Private Equity Fund Biotech. Applied Maths has units in Sint-Martens-Latem (Belgium) (head office) and Austin (USA). For further information, please visit the company's website: www.applied-maths.com.